The relationship between chronic oral inflammation and neurodegenerative disease has gained increasing attention, particularly in the context of periodontitis and Alzheimer’s disease (AD). Periodontitis is characterized by persistent inflammation and systemic dissemination of microbial products, which may contribute to neuroinflammatory processes associated with AD pathology. This study used a simulated dataset to examine whether individuals with periodontitis exhibit increased neuroinflammation and amyloid burden compared to healthy controls. Two independent groups (n = 25 each) were analyzed using Welch’s t-tests. Results showed significantly higher neuroinflammation and amyloid burden in the periodontitis group (p < 0.001 for both outcomes). These findings support a potential link between chronic peripheral inflammation and neurodegenerative processes. While simulated data limit clinical interpretation, the results highlight the biological plausibility of an association and suggest that oral health may represent a modifiable factor in Alzheimer’s disease risk.